Cardiac rehabilitation significantly reduced LDL-C (SMD -0.23; 95% CI -0.38, -0.08; P<0.001), triglycerides, and total cholesterol, while increasing HDL-C in coronary heart disease patients.
Meta-Analysis
Does comprehensive cardiac rehabilitation improve lipid levels in patients with coronary heart disease?
Comprehensive cardiac rehabilitation significantly improves lipid profiles, including reducing LDL-C, TG, and TC, and increasing HDL-C in patients with coronary heart disease.
Effect estimate: SMD -0.23 (95% CI -0.38, -0.08)
p-value: p=< 0.001
Background: Cardiac rehabilitation (CR) is a multidisciplinary medical program. Most studies have emphasized the effect of exercise-based CR in lowering lipid levels; however, the effect of CR as a comprehensive program on lipid levels remains unclear. Methods: Electronic database were searched up to 2022. Randomized controlled trials with lipid profile indicators were included. Standardized mean differences (SMDs) and 95% CIs were used to evaluate the effect size. Begg's funnel plot and Egger's linear regression test were used to assess publication bias. Results: CR remarkably reduced low-density lipoprotein cholesterol (LDL-C) levels (SMD = -0.23; 95%CI: -0.38, -0.08; P < 0.001), triglyceride (TG) levels (SMD = -0.17; 95%CI: -0.28, -0.06; P < 0.001), and total cholesterol (TC) levels (SMD = -0.30; 95%CI: -0.43, -0.16; P < 0.001) and increased high-density lipoprotein cholesterol (HDL-C) levels (SMD = 0.19; 95%CI: 0.10, 0.29; P < 0.001). Conclusions: CR reduce TC, TG, and LDL-C levels while improving HDL-C levels. CR should be promoted and more trials should be conducted for long-term CR.
Wu et al. (Tue,) conducted a meta-analysis in Coronary Heart Disease. Cardiac rehabilitation was evaluated on Low-density lipoprotein cholesterol (LDL-C) levels (SMD -0.23, 95% CI -0.38, -0.08, p=< 0.001). Cardiac rehabilitation significantly reduced LDL-C (SMD -0.23; 95% CI -0.38, -0.08; P<0.001), triglycerides, and total cholesterol, while increasing HDL-C in coronary heart disease patients.