December 6, 2022Open Access

Sulfation at Glycopolymer Side Chains Switches Activity at the Macrophage Mannose Receptor (CD206) In Vitro and In Vivo

FMFrancesca MastrottoUniversity of Padua MPMarco PirazziniUniversity of Padua SNSamuele NegroUniversity of Padua

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Abstract

-3-Gal glycopolymers inhibit CD206 both in vitro and in vivo, revealing hitherto unknown receptor function and demonstrating their potential as CD206 modulators within future immunotherapies.

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Mastrotto et al. (Tue,) studied this question.

synapsesocial.com/papers/69fc44bb6d64dccddbfa3ba4 https://doi.org/https://doi.org/10.1021/jacs.2c10757

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