Pregnancy in women with Eisenmenger syndrome resulted in severe complications, including a 27% maternal mortality rate and high rates of pre-eclampsia and fetal growth retardation.
Observational (n=11)
No
What are the maternal and fetal outcomes of pregnancy in women with Eisenmenger syndrome?
Pregnancy in Eisenmenger syndrome carries a very high risk of maternal mortality (27%) and fetal complications, reinforcing the need for early diagnosis, effective contraception, and early termination.
BACKGROUND: Despite advances in medical care, we still come across pregnancy in Eisenmenger syndrome. Eisenmenger syndrome represents the severe end of the spectrum for disease in pulmonary artery hypertension associated with CHD. Due to very high maternal and perinatal morbidity and mortality, pregnancy is contraindicated among these women. Current guidelines also recommend that the women who become pregnant should opt for early termination of pregnancy. Here, we present a case series of 11 women of Eisenmenger syndrome and their pregnancy outcome. METHODS: It was a retrospective analysis of 12 pregnancies among 11 women with Eisenmenger syndrome who were managed in a tertiary care referral centre of Northern India. RESULTS: The mean age of these women was 28 ± 4 years (range 22 to 36 years). Almost 80% of them (9/11) were diagnosed with Eisenmenger syndrome during pregnancy. The commonest cardiac lesion was Ventricular Septal defect (54.5%) followed by Atrial Septal defect (27.3%) and Patent Ductus arteriosus (9.1%). Only three women opted for medical termination of pregnancy, rest eight continued the pregnancy or presented late. Pregnancy complications found include pre-eclampsia (50%), abruption (22%), and fetal growth retardation (62.5%). There were three maternal deaths (mortality rate 27%) in postpartum period. CONCLUSION: This case series highlights the delay in diagnosis and treatment of CHD despite improvement in medical care. Women with Eisenmenger syndrome require effective contraception, preconceptional counselling, early termination of pregnancy, and multidisciplinary care.
Sharma et al. (Thu,) conducted a observational in Eisenmenger syndrome in pregnancy (n=11). Pregnancy in women with Eisenmenger syndrome resulted in severe complications, including a 27% maternal mortality rate and high rates of pre-eclampsia and fetal growth retardation.