YTHDF1 impairs antitumour immunity via an m6A-p65-CXCL1/CXCR2 axis to promote CRC and serves as a therapeutic target in immune checkpoint blockade therapy.

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Bao et al. (Mon,) studied this question.

synapsesocial.com/papers/69dc803824e766dc313594dd https://doi.org/https://doi.org/10.1136/gutjnl-2022-328845

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy2016 · 1,305 citations
2RNA modifications regulating cell fate in cancer2019 · 374 citations
3The complexity of NF-κB signaling in inflammation and cancer2013 · 3,198 citations
4IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade2017 · 3,873 citations
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