In patients with moderate-severe COPD, resting PaO2 was the only significant physiological predictor of both mean pulmonary artery pressure and pulmonary vascular resistance.
Observational (n=69)
No
What are the physiological predictors of resting pulmonary hypertension in patients with moderate-severe COPD?
In patients with moderate-severe COPD, resting arterial hypoxemia (PaO2) is a key predictor of resting pulmonary hypertension, independent of the degree of airflow obstruction or hyperinflation.
Effect estimate: Coefficient -0.29
p-value: p=0.005
Abstract Background Resting pulmonary hypertension (PH) is not uncommon in patients with chronic obstructive pulmonary disease (COPD). In the current study, we aimed to identify physiological predictors of resting PH in patients with COPD. Methods We retrospectively analyzed data derived from right heart catheterization in sixty-nine stable patients with COPD. Patients were categorized into COPD-PH ( n = 33) and COPD-non-PH ( n = 36), based on the “6 th World Symposium on PH.” Results Demographics, forced expiratory volume in 1 s (FEV 1 ), lung volumes, cardiac output, and cardiac index were similar between groups, yet COPD-PH had greater pulmonary vascular resistance (PVR) and lower resting PaO 2 ( P < 0.05). The proportion of COPD-PH patients did not differ across the range of FEV 1 ( χ 2 = 3.01, P = 0.22). No correlations were found between PVR and the degree of airflow obstruction or resting hyperinflation. Resting PaO 2 was the only predictor of both pulmonary artery pressure and PVR. Conclusions Increased PVR, in response to arterial hypoxemia or directly induced by tobacco smoking, is likely the key factor that led to resting PH in the current sample of patients with moderate-severe COPD, regardless of the degree of airflow limitation or resting hyperinflation.
Atta et al. (Thu,) conducted a observational in Chronic obstructive pulmonary disease (COPD) (n=69). Resting PaO2 was evaluated on Mean pulmonary artery pressure (mPAP) predicted by resting PaO2 (Coefficient -0.29, p=0.005). In patients with moderate-severe COPD, resting PaO2 was the only significant physiological predictor of both mean pulmonary artery pressure and pulmonary vascular resistance.