A high-salt diet in outbred, genetically diverse mice progressively increases systolic blood pressure and induces arterial dysfunction.
Does a high-salt diet increase systolic blood pressure and induce arterial dysfunction in outbred, genetically diverse mice?
A high-salt diet in outbred, genetically diverse mice progressively increases systolic blood pressure and induces arterial dysfunction, providing a translational model for human salt-induced hypertension.
Excess salt consumption is a contributor to hypertension and arterial dysfunction in humans living in industrialized societies, but this phenotype is not observed in inbred, genetically identical mice that consume a high-salt (HS) diet. This study reveals that a HS diet in outbred, genetically diverse mice progressively increases systolic blood pressure and induce arterial dysfunction. These data suggest that genetically diverse mice may provide translational insight into arterial adaptations in humans that consume an HS diet.
Zheng et al. (Fri,) conducted a other in Hypertension and arterial dysfunction. High-salt (HS) diet was evaluated on Systolic blood pressure and arterial dysfunction. A high-salt diet in outbred, genetically diverse mice progressively increases systolic blood pressure and induces arterial dysfunction.
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