Cumulative exposure to high insulin resistance from 15 to 24 years of age was negatively associated with 7-year arterial stiffness progression (effect estimate -0.021).
Cohort (n=1,779)
No
How are cumulative insulin resistance and hyperglycemia associated with arterial stiffness and carotid IMT progression in adolescents?
Cumulative high insulin and insulin resistance during adolescence are associated with arterial stiffness progression, suggesting age 17 may be an optimal time for targeted interventions.
Effect estimate: Effect estimate -0.021 (95% CI -0.039 to -0.004)
p-value: p=0.019
Fasting plasma glucose, insulin, and insulin resistance had a J- or U-shaped increase from 15 to 24 yr with the base of the curve at age 17 yr. Cumulative high insulin and high insulin resistance from 15 to 24 yr were negatively associated with arterial stiffness progression from ages 17 to 24 yr. Age 17 yr may be an optimal timing for intervention targeted at sustaining the protective effect of the decline of insulin and insulin resistance on arterial stiffness progression.
Agbaje et al. (Wed,) conducted a cohort in Healthy adolescents (n=1,779). Cumulative high HOMA-IR (≥75th percentile) vs. Moderate/normal HOMA-IR (<75th percentile) was evaluated on 7-year carotid-femoral pulse wave velocity (cfPWV) progression (Effect estimate -0.021, 95% CI -0.039 to -0.004, p=0.019). Cumulative exposure to high insulin resistance from 15 to 24 years of age was negatively associated with 7-year arterial stiffness progression (effect estimate -0.021).
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