Cats with thin and hypokinetic myocardial segments (THyMS) had advanced cardiomyopathy and a poor prognosis, with a median survival time of 153 days (95% CI 83-223 days).
Observational (n=80)
Yes
In cats with cardiomyopathy, thin and hypokinetic myocardial segments indicate advanced disease and are associated with a poor prognosis, with a median survival of 153 days.
Effect estimate: Median 153 days (95% CI 83-223 days)
INTRODUCTION/OBJECTIVES: Thin and hypokinetic myocardial segments (THyMS) represent adverse ventricular (LV) remodeling in human hypertrophic cardiomyopathy. We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopulation, the echocardiographic phenotype before LV wall thinning was detected (pre-THyMS). ANIMALS: Eighty client-owned cats. MATERIALS AND METHODS: Retrospective multicenter study. Clinical records were searched for cats with THyMS, defined as LV segment(s) with end-diastolic wall thickness (LVWT) 4 mm and normal wall motion. When available, echocardiograms pre-THyMS were assessed. Survival time was defined as time from first presentation with THyMS to death. RESULTS: Mean thickest LV wall segment (MaxLVWT) was 6.1 mm (95% CI 5.8-6.4 mm) and thinnest (MinLVWT) was 1.7 mm (95% CI 1.6-1.9 mm). The LV free wall was affected in 74%, apex in 13% and septum in 5%. Most cats (85%) presented with heart failure and/or arterial thromboembolism. Median circulating troponin I concentration was 1.4 ng/mL (range 0.07-180 ng/mL). Prior echocardiography results were available for 13/80 cats, a mean of 2.5 years pre-THyMS. In segments subsequently undergoing thinning, initial MaxLVWT measured 6.7 mm (95% CI 5.8-7.7 mm) vs. 1.9 mm (95% CI 1.5-2.4 mm) at last echocardiogram (P<0.0001). Survival data were available for 56/80 cats, median survival time after diagnosing THyMS was 153 days (95% CI 83-223 days). Cardiac histopathology in one cat revealed that THyMS was associated with severe transmural scarring. CONCLUSIONS: Cats with THyMS had advanced cardiomyopathy and a poor prognosis.
Matos et al. (Fri,) conducted a observational in Cardiomyopathy (n=80). Thin and hypokinetic myocardial segments (THyMS) was evaluated on Survival time from first presentation with THyMS to death (Median 153 days, 95% CI 83-223 days). Cats with thin and hypokinetic myocardial segments (THyMS) had advanced cardiomyopathy and a poor prognosis, with a median survival time of 153 days (95% CI 83-223 days).