Alterations in myocardial energy supply and mitochondrial function contribute to heart failure, highlighting substrate modulation as a potential therapeutic target.
PURPOSE OF REVIEW: Myocardial metabolism is intricately linked to cardiac function. Perturbations of cardiac energy metabolism result in an energy-starved heart and the development of contractile dysfunction. In this review, we discuss alterations in myocardial energy supply, transcriptional changes in response to different energy demands, and mitochondrial function in the development of heart failure. RECENT FINDINGS: Recent studies on substrate modulation through modifying energy substrate supply have shown cardioprotective properties. In addition, large cardiovascular outcome trials of anti-diabetic agents have demonstrated prognostic benefit, suggesting the importance of myocardial metabolism in cardiac function. Understanding molecular and transcriptional controls of cardiac metabolism promises new research avenues for metabolic treatment targets. Future studies assessing the impact of substrate modulation on cardiac energetic status and function will better inform development of metabolic therapies.
Ng et al. (Wed,) conducted a review in Heart Failure. Substrate modulation was evaluated. Alterations in myocardial energy supply and mitochondrial function contribute to heart failure, highlighting substrate modulation as a potential therapeutic target.