Higher high frequency norm was independently associated with better MMSE (β=0.051; 95% CI 0.012-0.090; p=0.011) and MoCA scores among patients with cerebral small vessel disease.
Cross-Sectional (n=117)
Does heart rate variability correlate with cognitive performance in patients with cerebral small vessel disease?
In patients with cerebral small vessel disease, higher parasympathetic tone (HF norm) correlates with better cognitive performance, whereas higher sympathetic dominance (LF/HF ratio) correlates with worse cognitive performance.
Effect estimate: β 0.051 (95% CI 0.012~0.090)
p-value: p=0.011
Data linking heart rate variability (HRV) and cognitive status remains controversial and scarce, particularly in cerebral small vessel disease (CSVD) patients. Whether the association between HRV and cognitive performance exists in CSVD patients is unclear. Hence, we aimed to investigate the association between HRV and cognitive performance in patients with CSVD. This cross-sectional study was conducted among 117 CSVD patients. All patients underwent HRV assessment and global cognitive evaluation by the Mini-Mental-State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Multivariable analyses were performed to evaluate the association between HRV and cognitive status. The mean age of study population was 59.5 ± 11.8 years and 39.3% were female. After adjusting for confounding factors, a higher high frequency (HF) norm was independently associated with better MMSE scores (β = 0.051; 95% confidence interval (CI): 0.012~0.090; p = 0.011) and MoCA scores (β = 0.061; 95% CI: 0.017~0.105; p = 0.007), while a higher low frequency (LF)/HF ratio was independently associated with worse MMSE scores (β = −0.492; 95% CI: −0.893~−0.092; p = 0.017) and MoCA scores (β = −0.691; 95% CI: −1.134~−0.248; p = 0.003). The HF norm was positively associated with global cognitive performance, whereas the LF/HF ratio was negatively associated with global cognitive performance among CSVD patients. Further study of the relationship between autonomic function and cognitive performance is warranted.
Hu et al. (Fri,) conducted a cross-sectional in Cerebral small vessel disease (n=117). Heart rate variability (HRV) parameters was evaluated on Global cognitive evaluation by MMSE and MoCA scores (β 0.051, 95% CI 0.012~0.090, p=0.011). Higher high frequency norm was independently associated with better MMSE (β=0.051; 95% CI 0.012-0.090; p=0.011) and MoCA scores among patients with cerebral small vessel disease.