Left ventricular global longitudinal strain correlated with coronary artery disease severity, showing mean GLS of -15.6, -13.5, and -11.02 for single, double, and triple-vessel disease respectively.
Observational (n=105)
No
Does left ventricular global longitudinal strain (GLS) predict the extent of coronary artery disease and future cardiovascular events in patients with non ST-elevation myocardial infarction?
Left ventricular global longitudinal strain assessed by speckle tracking echocardiography correlates with the angiographic severity of coronary artery disease in patients with NSTEMI.
Background: Coronary artery disease (CAD) has assumed epidemic proportions in the world. Accurate risk stratification and early invasive management when indicated can reduce morbidity and mortality substantially. The study aims to correlate left ventricular (LV) function assessed by global longitudinal strain (GLS) with the extent of CAD in patients with myocardial infarction (MI). Methods: The study was conducted in a tertiary care hospital in Southern India. A total of 105 patients admitted with a diagnosis of non ST-elevation MI were included. All patients had a detailed echocardiogram with the evaluation of LV GLS by two-dimensional speckle tracking echocardiography and ejection fraction by Simpson's method. Coronary angiogram was also done in all patients to study the coronary anatomy and the relation between CAD and LV GLS. Results: The mean age of study population was 53.9 years. Echocardiographic study revealed mean LV ejection fraction (LVEF) was 48.16 + 12.27. The mean LVEF in patients with single-vessel disease was 50.11 + 11.62; with two-vessel disease, it was 51.81 + 10.34, and in patients with triple-vessel disease, it was 41.5 + 11.8. The mean GLS in the abovementioned groups was − 15.6 + 3.33, −13.5 + 3.2, and − 11.02 + 4.14, respectively. The follow-up of patients also showed a considerably lower GLS in patients who suffered higher morbidity and mortality. Conclusion: LV GLS is a good noninvasive predictor of the burden of CAD on the angiogram and also a predictor of future cardiovascular events and mortality.
Kumar et al. (Sex,) realizaram um estudo observacional em infarto do miocárdio sem elevação do segmento ST (n=105). A deformação longitudinal global do ventrículo esquerdo (GLS) foi avaliada em correlação com a extensão da doença arterial coronariana. A deformação longitudinal global do ventrículo esquerdo apresentou correlação com a gravidade da doença arterial coronariana, mostrando GLS média de -15,6, -13,5 e -11,02 para doença de um, dois e três vasos, respectivamente.