Estimation of Life’s Essential 8 Score with Incomplete Data of Individual Metrics

Abstract Background The American Heart Association’s Life’s Essential 8 (LE8) is an updated construct of cardiovascular health (CVH), including blood pressure, lipids, glucose, body mass index, nicotine exposure, diet, physical activity, and sleep health. It is challenging to simultaneously measure all eight metrics at multiple time points in most research and clinical settings, hindering the use of LE8 to assess individuals’ overall CVH trajectories over time. Methods and Results We obtained data from 5,588 participants in the Nurses’ Health Studies (NHS, NHSII) and Health Professional’s Follow-up Study (HPFS), and 27,194 participants in the 2005-2016 National Health and Nutrition Examination Survey (NHANES) with all eight metrics available. Individuals’ overall cardiovascular health (CVH) was determined by LE8 score (0-100). CVH-related factors that are routinely collected in many settings (i.e., demographics, BMI, smoking, hypertension, hypercholesterolemia, and diabetes) were included as predictors in the base models of LE8 score, and subsequent models further included less frequently measured factors (i.e., physical activity, diet, blood pressure, and sleep health). Gradient boosting decision trees were trained with hyper-parameters tuned by cross-validations. The base models trained using NHS, NHSII, and HPFS had validated root mean squared errors (RMSEs) of 8.06 (internal) and 16.72 (external). Models with additional predictors further improved performance. Consistent results were observed in models trained using NHANES. The predicted CVH scores can generate consistent effect estimates in associational studies as the observed CVH scores. Conclusions CVH-related factors routinely measured in many settings can be used to accurately estimate individuals’ overall CVH when LE8 metrics are incomplete. Clinical Perspective What Is New? Life’s Essential 8 (LE8) has great potential to assess and promote cardiovascular health (CVH) across life course, however, it is challenging to simultaneously collect all eight metrics at multiple time points in most research and clinical settings. We demonstrated that CVH-related factors routinely collected in many research and clinical settings can be used to accurately estimate individuals’ overall CVH across time even when LE8 metrics are incomplete. What Are the Clinical Implications? The approach introduced in this study provides a cost-effective and feasible way to estimate individuals’ overall CVH. It can be used to track individuals’ CVH trajectories in clinical settings.