Dynamic 3D deuterium metabolic imaging with oral [6,6’-2H2]-glucose demonstrated low intrasession variability in the liver (5.6%) and right kidney (4.9%) in healthy volunteers.
DMI with oral administration of [6,6'-2H2]-glucose enables simultaneous noninvasive assessment of gastric emptying and liver and kidney glucose uptake and metabolism.
Abstract Deuterium metabolic imaging (DMI) is a novel noninvasive method to assess tissue metabolism and organ (patho)physiology in vivo using deuterated substrates, such as 6,6’‐ 2 H 2 ‐glucose. The liver and kidneys play a central role in whole‐body glucose homeostasis, and in type 2 diabetes, both hepatic and renal glucose metabolism are dysregulated. Diabetes is also associated with gastric emptying abnormalities. In this study, we developed a four‐channel 2 H transmit/receive body array coil for DMI in the human abdomen at 7 T and assessed its performance. In addition, the feasibility of simultaneously measuring gastric emptying, and hepatic and renal glucose uptake and metabolism with dynamic 3D DMI upon administration of deuterated glucose, was investigated. Simulated and measured B 1 + patterns were in good agreement. The intrasession variability of the natural abundance deuterated water signal in the liver and right kidney, measured in nine healthy volunteers, was 5.6% ± 0.9% and 4.9% ± 0.7%, respectively. Dynamic 3D DMI scans with oral administration of 6,6’‐ 2 H 2 ‐glucose showed similar kinetics of deuterated glucose appearance and disappearance in the liver and kidney. The measured gastric emptying half time was 80 ± 10 min, which is in good agreement with scintigraphy measurements. In conclusion, DMI with oral administration of 6,6’‐ 2 H 2 ‐glucose enables simultaneous assessment of gastric emptying and liver and kidney glucose uptake and metabolism. When applied in patients with diabetes, this approach may advance our understanding of the interplay between disturbances in liver and kidney glucose uptake and metabolism and gastric emptying, at a detail that cannot be achieved by any other method.
Gürsan et al. (Thu,) conducted a other in Healthy (n=9). Dynamic 3D deuterium metabolic imaging with oral [6,6’-2H2]-glucose was evaluated on Intrasession variability of natural abundance deuterated water signal in the liver and right kidney. Dynamic 3D deuterium metabolic imaging with oral [6,6’-2H2]-glucose demonstrated low intrasession variability in the liver (5.6%) and right kidney (4.9%) in healthy volunteers.