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PD exacerbates atherosclerosis and impairs lipid metabolism in mice, which may be mediated by F. nucleatum-promoted glycolysis and lipogenesis through PI3K/Akt/mTOR signalling in hepatocytes. Treatment of PD and specific targeting of F. nucleatum are promising strategies to improve therapeutic effectiveness of hyperlipidaemia and atherosclerosis.
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Lu‐Jun Zhou
Wen-Zhen Lin
Xiao-Qian Meng
Cardiovascular Research
Shanghai Jiao Tong University
Tongji University
Air Force Medical University
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Zhou et al. (Mon,) studied this question.
www.synapsesocial.com/papers/69d8924705ee2ba81dbefc6d — DOI: https://doi.org/10.1093/cvr/cvad045
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