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Together, these data reveal the unprecedented endothelial cofilin-1/PP2AC signaling axis downstream of metformin in protecting against lung vascular endothelial injury and inflammation. Therefore, pharmacologically enhancing endothelial PP2AC activity may lead to the development of novel therapeutic approaches for prevention of deleterious effects of ALI on vascular ECs.
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Mohammad R. Siddiqui
Narsa M. Reddy
Hafeez Faridi
Frontiers in Pharmacology
Northwestern University
Rush University Medical Center
Lurie Children's Hospital
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Siddiqui et al. (Thu,) studied this question.
www.synapsesocial.com/papers/6a03f66dcdf9ec677a893522 — DOI: https://doi.org/10.3389/fphar.2023.1211460
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