Extensive surgery for acute type A aortic dissection showed no significant difference in surgical mortality or overall survival compared to a conservative approach.
Cohort (n=601)
Yes
Does extensive surgery improve early- and medium-term outcomes compared to a conservative approach in patients with acute Type A aortic dissection?
In patients with acute Type A aortic dissection, extensive surgery does not significantly improve surgical mortality or overall survival compared to a conservative approach, but is associated with longer ICU stays.
Type A acute aortic dissection is associated with significant morbidity and mortality, with prompt referral imaging and management to tertiary referral centers needed urgently. Surgery is usually needed emergently, but the choice of surgery often varies depending on the patient and the presentation. Staff and center expertise also play a major role in determining the surgical strategy employed. The aim of this study was to compare the early- and medium-term outcomes of patients undergoing a conservative approach extended only to the ascending aorta and the hemiarch to those of patients subjected to extensive surgery (total arch reconstruction and root replacement) across three European referral centers. A retrospective study was conducted across three sites between January 2008 and December 2021. In total, 601 patients were included within the study, of which 30% were female, and the median age was 64.4 years. The most common operation was ascending aorta replacement (n = 246, 40.9%). The aortic repair was extended proximally (i.e., root n = 105; 17.5%) and distally (i.e., arch n = 250; 41.6%). A more extensive approach, extending from the root to the arch, was employed in 24 patients (4.0%). Operative mortality occurred in 146 patients (24.3%), and the most common morbidity was stroke (75, 12.6%). An increased length of ICU admission was noted in the extensive surgery group, which comprised younger and more frequently male patients. No significant differences were noted in surgical mortality between patients managed with extensive surgery and those managed conservatively. However, age, arterial lactate levels, “intubated/sedated” status on arrival, and “emergency or salvage” status at presentation were independent predictors of mortality both within the index hospitalization and during the follow-up. The overall survival was similar between the groups.
Nappi et al. (Fri,) conducted a cohort in Acute Type A Aortic Dissection (n=601). Extensive surgery (total arch reconstruction and root replacement) vs. Conservative approach (extended only to the ascending aorta and the hemiarch) was evaluated on Surgical mortality and overall survival. Extensive surgery for acute type A aortic dissection showed no significant difference in surgical mortality or overall survival compared to a conservative approach.