Patient-day-level models incorporating daily LAPS2 (c-statistic 0.772-0.878) outperformed models with admission LAPS2 alone (c-statistic 0.768-0.867) for predicting 30-day in-hospital mortality.
Cohort (n=13,993)
Yes
Does a model incorporating daily, time-updating LAPS2 improve prediction of in-hospital mortality in ICU patients compared to admission LAPS2 alone?
Incorporating daily, time-updating LAPS2 improves the prediction of 30-day in-hospital mortality among ICU patients compared to using admission scores alone.
BACKGROUND: Mortality prediction for intensive care unit (ICU) patients frequently relies on single ICU admission acuity measures without accounting for subsequent clinical changes. OBJECTIVE: Evaluate novel models incorporating modified admission and daily, time-updating Laboratory-based Acute Physiology Score, version 2 (LAPS2) to predict in-hospital mortality among ICU patients. RESEARCH DESIGN: Retrospective cohort study. PATIENTS: ICU patients in 5 hospitals from October 2017 through September 2019. MEASURES: We used logistic regression, penalized logistic regression, and random forest models to predict in-hospital mortality within 30 days of ICU admission using admission LAPS2 alone in patient-level and patient-day-level models, or admission and daily LAPS2 at the patient-day level. Multivariable models included patient and admission characteristics. We performed internal-external validation using 4 hospitals for training and the fifth for validation, repeating analyses for each hospital as the validation set. We assessed performance using scaled Brier scores (SBS), c -statistics, and calibration plots. RESULTS: The cohort included 13,993 patients and 107,699 ICU days. Across validation hospitals, patient-day-level models including daily LAPS2 (SBS: 0.119-0.235; c -statistic: 0.772-0.878) consistently outperformed models with admission LAPS2 alone in patient-level (SBS: 0.109-0.175; c -statistic: 0.768-0.867) and patient-day-level (SBS: 0.064-0.153; c -statistic: 0.714-0.861) models. Across all predicted mortalities, daily models were better calibrated than models with admission LAPS2 alone. CONCLUSIONS: Patient-day-level models incorporating daily, time-updating LAPS2 to predict mortality among an ICU population performs as well or better than models incorporating modified admission LAPS2 alone. The use of daily LAPS2 may offer an improved tool for clinical prognostication and risk adjustment in research in this population.
Kohn et al. (Mon,) conducted a cohort in Intensive care unit (ICU) patients (n=13,993). Patient-day-level models including daily LAPS2 vs. Models with admission LAPS2 alone was evaluated on In-hospital mortality within 30 days of ICU admission. Patient-day-level models incorporating daily LAPS2 (c-statistic 0.772-0.878) outperformed models with admission LAPS2 alone (c-statistic 0.768-0.867) for predicting 30-day in-hospital mortality.