An elevated monocyte-to-HDL cholesterol ratio was a significant independent predictor of overall mortality in patients with severe aortic stenosis undergoing TAVR (95% CI 1.11-3.38; P=0.018).
Cohort (n=125)
Does the monocyte-HDL cholesterol ratio (MHR) predict overall and cardiovascular mortality in patients with severe aortic stenosis undergoing TAVR?
The monocyte-HDL cholesterol ratio (MHR) may serve as a novel, independent prognostic marker for all-cause mortality in patients undergoing TAVR for severe aortic stenosis.
p-value: p=0.018
BACKGROUND: Inflammation plays a significant role in the pathogenesis of aortic stenosis. This study aimed to investigate the prognostic value of the monocyte-HDL cholesterol ratio (MHR), a new inflammatory marker, in severe aortic stenosis (AS) patients who underwent transcatheter aortic valve replacement (TAVR). METHODS: A total of 125 patients with severe AS who underwent TAVR were assessed. Clinical, echocardiographic and laboratory data relevant to the research were retrospectively obtained from the patients' records. The MHR was determined by dividing the absolute monocyte count by the HDL-C value. The primary endpoints were overall and cardiovascular mortality. RESULTS: = 0.018; 95% CI: 1.11-3.38) were found to be significant predictors of overall mortality. CONCLUSIONS: This study showed a significant elevation in the MHR among patients who experienced all-cause and cardiovascular mortality and this ratio emerged as an independent predictor of all-cause death in patients with severe AS undergoing TAVR.
Mercean et al. (Tue,) conducted a cohort in Severe aortic stenosis (n=125). Monocyte to High-Density Lipoprotein Cholesterol Ratio (MHR) was evaluated on Overall and cardiovascular mortality (95% CI 1.11-3.38, p=0.018). An elevated monocyte-to-HDL cholesterol ratio was a significant independent predictor of overall mortality in patients with severe aortic stenosis undergoing TAVR (95% CI 1.11-3.38; P=0.018).