Continuous flow from left ventricular assist devices predisposes patients to right-sided heart failure and aortic insufficiency, which manifest as time-dependent hemodynamic-related events.
Continuous flow LVADs predispose patients to hemodynamic-related events like right-sided heart failure and aortic insufficiency, which require distinct mitigation strategies from hemocompatibility-related events.
Left ventricular assist devices (LVADs) provide lifesaving therapy for patients with advanced heart failure. The recognition of pump thrombosis, stroke, and nonsurgical bleeding as hemocompatibility-related adverse events (HRAEs) led to pump design improvements and reduced adverse event rates. However, continuous flow can predispose patients to right-sided heart failure (RHF) and aortic insufficiency (AI), especially as patients live longer with their device. Given the hemodynamic contributions to AI and RHF, these comorbidities can be classified as hemodynamic-related events (HDREs). Hemodynamic-driven events are time dependent and often manifest later than HRAEs. This review examines the emerging strategies to mitigate HDREs, with a focus on defining best practices for AI and RHF. As we head into the next generation of LVAD technology, it is important to differentiate HDREs from HRAEs so that we can continue to advance the field and improve the true durability of the pump-patient continuum.
Grinstein et al. (Mon,) conducted a review in Advanced heart failure. Continuous Left Ventricular Mechanical Support (LVADs) was evaluated. Continuous flow from left ventricular assist devices predisposes patients to right-sided heart failure and aortic insufficiency, which manifest as time-dependent hemodynamic-related events.
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