Exercise training significantly improved endothelial function, measured by flow-mediated dilation, by a mean difference of 1.67% compared to no-exercise controls in adults with overweight and obesity.
Meta-Analysis (n=400)
Does exercise training improve endothelial function in adults with overweight and obesity?
Aerobic exercise training, but not resistance training, significantly improves endothelial function measured by flow-mediated dilation in adults with overweight and obesity.
Effect estimate: MD 1.67% (95% CI 0.97-2.37)
p-value: p=<0.001
Abstract The objective of this systematic review was to examine the effects of exercise training on endothelial function in individuals with overweight and obesity. Our review study included only randomized controlled trials (RCTs) involving adults (≥ 18 years of age) with body mass index (BMI) ≥ 25.0 kg/m 2 . Our search was conducted in the electronic bases MEDLINE (PubMed), Cochrane, LILACS and EMBASE and in the gray literature. We performed random-effects analyses for effect estimates and used 95% prediction intervals (95% PI) for estimating the uncertainty of the study results. There were selected 10 RCTs involving 14 groups (n = 400). The quality assessment of studies using Cochrane risk-of-bias 2 (RoB 2) tool identified some concerns. Exercise training resulted in improved flow-mediated dilation (FMD) in individuals with overweight and obesity (p < 0.001) compared to the no-exercise control group. This effect of training modalities on FMD was seen for aerobic training (p < 0.001) but not for resistance training (p = 0.051). There was no difference in FMD in response to exercise training by BMI classification (overweight, obesity, overweight + obesity), p = 0.793. The present results are consistent with the notion that aerobic exercise training elicits favorable adaptations in endothelial function in individuals with overweight and obesity. Our findings should be interpreted with caution because of the small number of studies included in this review.
Cortes et al. (Fri,) conducted a meta-analysis in Overweight and obesity (n=400). Exercise training (aerobic or resistance) vs. No-exercise control was evaluated on Endothelial function measured by brachial artery flow-mediated dilation (FMD) (MD 1.67%, 95% CI 0.97-2.37, p=<0.001). Exercise training significantly improved endothelial function, measured by flow-mediated dilation, by a mean difference of 1.67% compared to no-exercise controls in adults with overweight and obesity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: