A 52-week multidisciplinary cardiac rehabilitation intervention had no effect on left ventricular ejection fraction compared to usual care in patients with breast cancer.
RCT (n=74)
Does a multidisciplinary model of cardiac rehabilitation prevent cardiotoxicity (LVEF reduction) in patients with stage I to III breast cancer receiving anthracycline and/or trastuzumab-based chemotherapy?
A 52-week multidisciplinary cardiac rehabilitation intervention did not prevent LVEF reduction or improve biomarkers of cardiotoxicity in breast cancer patients undergoing chemotherapy, though it did improve lipid profiles.
Cardiac rehabilitation (CR) modeled care is recommended for patients with breast cancer to mitigate risk of cardiotoxicity. However, the cardiovascular impact of CR-modeled interventions has not been studied. The purpose of this study was to evaluate if a multidisciplinary model of CR reduces cardiotoxicity and improves cardiovascular risk in patients undergoing breast cancer treatment. We randomly assigned patients with stage I to III breast cancer scheduled to receive anthracycline and/or trastuzumab-based chemotherapy to the CR intervention (n = 37) or usual care (n = 37). The intervention included guideline-directed management of cardiovascular risk factors, dietary counselling, and supervised exercise for 52 weeks. Cardiac magnetic resonance imaging, cardiopulmonary exercise testing, dual-energy x-ray absorptiometry, and serum biomarkers were acquired at baseline and 52 weeks. There was no difference in the primary outcome, left ventricular ejection fraction (LVEF), between groups at 52 weeks (61% ± 6%). Other markers of cardiotoxicity, including high-sensitivity troponin I and brain natriuretic peptide, were similar between groups. However, total cholesterol (5.2 ± 0.8-4.7 ± 0.8 mmol/L, P = 0.002) and low-density lipoprotein (3.0 ± 0.7-2.4 ± 0.7 mmol/L, P < 0.001) decreased in the intervention group at 52 weeks and were unchanged in usual care. In all patients, adverse cardiac and metabolic changes occurred over 52 weeks including reductions in LVEF, left ventricular mass, high-density lipoprotein, lean body mass, insulin-like growth factor-1, as well as increased triglycerides, whole-body and truncal fat mass (all P < 0.050). The CR-modeled intervention had no effect on LVEF or biomarkers of cardiotoxicity. Future lifestyle intervention trials in patients with breast cancer should consider targeting other risk factors associated with incident cardiovascular disease. (Multidisciplinary Team IntervenTion in CArdio-ONcology TITAN Study TITAN; NCT01621659)
Kirkham et al. (Thu,) conducted a rct in Breast cancer (n=74). Cardiac rehabilitation (CR) intervention vs. Usual care was evaluated on Left ventricular ejection fraction (LVEF). A 52-week multidisciplinary cardiac rehabilitation intervention had no effect on left ventricular ejection fraction compared to usual care in patients with breast cancer.