Percutaneous patent foramen ovale closure led to a significantly higher incidence of new-onset atrial fibrillation compared to conservative treatment (5.1% vs. 1.6%, OR 3.17).
Meta-Analysis (n=9,552)
Does percutaneous PFO closure increase the incidence of new-onset atrial fibrillation compared to conservative medical treatment in patients with cryptogenic stroke or TIA?
Percutaneous PFO closure is associated with a significantly higher incidence of new-onset atrial fibrillation compared to conservative medical therapy, with detection rates heavily dependent on the intensity of rhythm surveillance.
Odds Ratio: 3.17 (95% CI 1.46–6.86)
Absolute Event Rate: 5.1% vs 1.6%
p-value: p=0.03
Abstract Background The exact incidence and predictors of new-onset atrial fibrillation (AF) after percutaneous closure of patent foramen ovale (PFO) are unknown. Objective We sought to find post-procedural AF incidence rates and differences due to different screening strategies and devices. Methods A systematic search was conducted in Cochrane, MEDLINE and EMBASE. Controlled trials fulfilling the inclusion criteria were included into this meta-analysis. The incidence of new-onset AF was the primary outcome. Further parameters were surveillance strategy, device type, AF treatment and neurological events. New AF was determined as early onset within one month after implantation and late thereafter. Results 8 controlled trials and 16 cohort studies were eligible for quantitative analysis. 7643 patients received percutaneous PFO closure after cryptogenic stroke or transient ischaemic attack, 117 with other indications, whereas 1792 patients formed the control group. Meta-analysis of controlled trials showed an AF incidence of 5.1% in the interventional and 1.6% in the conservative arm, respectively (OR 3.17, 95% CI 1.46–6.86, P = 0.03, I 2 = 55%). 4.7% received high-quality surveillance strategy with Holter-ECG or Loop recorder whereby AF incidence was overall higher compared to the low-quality group with 12-lead ECG only (3.3–15% vs. 0.2–4.3%). Heterogeneous results on time of AF onset were found, limited by different follow-up strategies. CardioSEAL and Starflex seemed to have higher AF incidences in early and late onset with 4.5% and 4.2%, respectively. Conclusion Percutaneous PFO closure led to higher AF post-procedural incidence compared to the conservative strategy. Heterogeneity in surveillance and follow-up strategy limited the generalizability. Trial Registration Registered on PROSPERO (CRD42022359945). Graphical abstract
Jurczyk et al. (Sat,) conducted a meta-analysis in Patent foramen ovale with cryptogenic stroke or transient ischaemic attack (n=9,552). Percutaneous patent foramen ovale closure vs. Conservative treatment was evaluated on Incidence of new-onset atrial fibrillation (OR 3.17, 95% CI 1.46-6.86, p=0.03). Percutaneous patent foramen ovale closure led to a significantly higher incidence of new-onset atrial fibrillation compared to conservative treatment (5.1% vs. 1.6%, OR 3.17).