Does combined treatment with β-blockers and ACE inhibitors or ARBs prevent the recurrence of takotsubo syndrome compared to monotherapies?
Combined therapy with beta-blockers and ACEi/ARBs may be more effective than monotherapy in preventing the rare short-term recurrence of takotsubo syndrome.
Recurrence and phenotypic change of TTS are rare. Some cases have been reported but occurring months to years after initial diagnosis. Combined treatment with β-blockers and angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists may be more effective to prevent the recurrence than monotherapies.
Saito et al. (Tue,) studied this question.