Physiological indices including respiratory rate, systolic blood pressure, and BMI significantly affect resting-state fMRI-derived brain entropy, which also maintains regional associations with cognition.
Observational (n=1,206)
Resting-state fMRI-derived brain entropy is significantly influenced by physiological factors such as respiratory rate, systolic blood pressure, and BMI, which must be accounted for when evaluating its relationship with cognition.
p-value: p=<0.05
BACKGROUND: In recent years, resting-state fMRI (rsfMRI)-based brain entropy (BEN) has gained increasing interest as a tool to characterize brain activity. While previous studies indicate that BEN is correlated with cognition, it remains unclear whether BEN is influenced by other factors that typically affect brain activity measured by fMRI. PURPOSE: To investigate the relationship between BEN and physiological indices, including respiratory rate (RR), heart rate (HR), systolic blood pressure (s-BP), and body mass index (BMI), and to investigate whether and to what extent the relationship between BEN and cognition is influenced by physiological variables. STUDY TYPE: Retrospective. SUBJECTS: One thousand two hundred six healthy subjects (mean age: 28.83 ± 3.69 years; 550 male) with rsfMRI datasets selected from the Human Connectome Project (HCP). FIELD STRENGTH/SEQUENCE: Multiband echo planar imaging (EPI) sequence at 3.0 Tesla. ASSESSMENT: Neurocognitive, physical health (RR, HR, s-BP, BMI), and rsfMRI data were retrieved from the HCP datasets. Neurocognition was measured through the total cognition composite (TCC) score provided by HCP. BEN maps were calculated from rsfMRI data. STATISTICAL TESTS: -FWE < 0.05 were considered statistically significant. RESULTS: BEN was negatively associated with RR (T-thresholds ranging from 4.75 to 4.8; r-threshold = |0.15|) and positively associated with s-BP and BMI (T-thresholds ranging from 4.75 to 4.8; r-threshold = |0.15|) in areas overlapping with the default mode network. After controlling the physiological effects, BEN still showed regional associations with TCC, including negative associations (T-thresholds = 3.09; r-threshold = |0.1|) in the fronto-parietal cortex and positive associations (T-thresholds = 3.09; r-threshold = |0.1|) in the sensorimotor system (motor network and the limbic system). DATA CONCLUSIONS: RR negatively affects rsfMRI-derived BEN, while s-BP and BMI positively affect BEN. The positive associations between BEN and cognition in the motor network and the limbic system might indicate a facilitation of information processing in the sensorimotor system. EVIDENCE LEVEL: 3 TECHNICAL EFFICACY: Stage 3.
Mauro et al. (Mon,) conducted a observational in Healthy (n=1,206). Physiological indices (respiratory rate, systolic blood pressure, body mass index) was evaluated on Association of brain entropy with physiological indices and cognition (p=<0.05). Physiological indices including respiratory rate, systolic blood pressure, and BMI significantly affect resting-state fMRI-derived brain entropy, which also maintains regional associations with cognition.