Combined RAF and MEK Inhibition to Treat Activated Non-V600 BRAF-Altered Advanced Cancers

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Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF2004 · 2,799 citations
2. 2^V600E BRAF is associated with disabled feedback inhibition of RAF–MEK signaling and elevated transcriptional output of the pathway2009 · 614 citations