Semaglutide (2.4 mg) significantly improved symptoms, physical limitations, exercise function, and caused greater weight loss compared to placebo in heart failure patients with preserved ejection frac
Does semaglutide (2.4 mg) improve symptoms, physical limitations, exercise function, and weight loss in patients with heart failure with preserved ejection fraction and obesity?
Patients with heart failure with preserved ejection fraction and obesity
Semaglutide (2.4 mg)
Placebo
Reductions in symptoms and physical limitations, improvements in exercise function, and weight losspatient reported
In patients with HFpEF and obesity, semaglutide 2.4 mg significantly improves heart failure symptoms, physical limitations, and exercise function while promoting weight loss.
In patients with heart failure with preserved ejection fraction and obesity, treatment with semaglutide (2.4 mg) led to larger reductions in symptoms and physical limitations, greater improvements in exercise function, and greater weight loss than placebo. (Funded by Novo Nordisk; STEP-HFpEF ClinicalTrials.gov number, NCT04788511.).
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Mikhail Kosiborod
Steen Z. Abildstrøm
Barry A. Borlaug
New England Journal of Medicine
Mayo Clinic
University of Missouri–Kansas City
Gentofte Hospital
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Kosiborod et al. (Fri,) reported a other. Semaglutide (2.4 mg) significantly improved symptoms, physical limitations, exercise function, and caused greater weight loss compared to placebo in heart failure patients with preserved ejection frac.
www.synapsesocial.com/papers/6967cf2de36b71fd5d83144e — DOI: https://doi.org/10.1056/nejmoa2306963