Does catheter ablation combined with guideline-directed medical therapy reduce the composite of death, LVAD implantation, or urgent heart transplantation in patients with atrial fibrillation and end-stage heart failure?
Patients with atrial fibrillation and end-stage heart failure
Catheter ablation combined with guideline-directed medical therapy
Guideline-directed medical therapy alone
Composite of death from any cause, implantation of a left ventricular assist device, or urgent heart transplantationcomposite
In patients with end-stage heart failure and atrial fibrillation, adding catheter ablation to medical therapy reduces the composite risk of mortality, LVAD implantation, or urgent heart transplantation.
Among patients with atrial fibrillation and end-stage heart failure, the combination of catheter ablation and guideline-directed medical therapy was associated with a lower likelihood of a composite of death from any cause, implantation of a left ventricular assist device, or urgent heart transplantation than medical therapy alone. (Funded by Else Kröner-Fresenius-Stiftung; CASTLE-HTx ClinicalTrials.gov number, NCT04649801.).
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Christian Sohns
Electrophysiology
Henrik Fox
Heart and Diabetes Center North Rhine-Westphalia
Nassir Marrouche
Electrophysiology
New England Journal of Medicine
University of Amsterdam
Charité - Universitätsmedizin Berlin
Maastricht University
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Sohns et al. (Sun,) studied this question.
synapsesocial.com/papers/69d56fa775589c71d767da24 — DOI: https://doi.org/10.1056/nejmoa2306037