Coronary inflammation was significantly higher in CAD patients compared to non-CAD patients (-87.54 vs. -93.45 HU, P=0.000), but did not correlate with coronary artery calcium score severity.
Cross-Sectional (n=346)
Coronary inflammation measured by PCAT attenuation is most pronounced in CAD patients with a zero calcium score, indicating that inflammation may not directly correlate with calcified atherosclerotic burden.
Absolute Event Rate: -87.54% vs -93.45%
p-value: p=0.000
Background: As for the coronary artery inflammation and coronary atherosclerotic burden, which are used to assess the risk of adverse cardiac events in patients, it is unclear whether there is any certain correlation between them. Therefore, the purpose of this study was to explore the potential relationship between coronary artery inflammation and coronary atherosclerotic burden. Methods: A total of 346 eligible patients underwent assessment of computed tomography (CT) attenuation values of pericoronary adipose tissue (PCAT) in the right coronary artery and Agatston coronary artery calcium (CAC) based on coronary CT angiography. These measurements were utilized to evaluate coronary inflammation and atherosclerotic burden, respectively. Patients with a CAC score of 0 were categorized into groups based on the presence or absence of coronary artery disease (CAD). CAC scores of 10, 100, and 400 were chosen as cutoff values to compare differences in PCAT attenuation values across different CAC scores. Results: When comparing all CAD patients to non-CAD patients, a significantly higher PCAT attenuation was observed in CAD patients (−87.54±9.39 vs. −93.45±7.42 HU, P=0.000). The PCAT attenuation in CAD patients with a CAC score of 0 was significantly higher than that in patients with a CAC score greater than 0 and in non-CAD patients with a CAC score of 0 (−82.63±8.70 vs. −90.38±8.59 vs. −93.45±7.42 HU, P=0.000). The PCAT attenuation values did not exhibit significant differences among different CAC scores (all P>0.05); however, it was highest in CAD patients with a CAC score of 0 (P<0.05). Body mass index, hyperlipidemia, hypertension, and PCAT attenuation were identified as independent risk factors in both CAD patients with a CAC score of 0 and patients with a CAC score greater than 0 (all P<0.05). Conclusions: The results of this study suggest that a direct relationship between coronary inflammation and coronary atherosclerotic burden is not evident. Nonetheless, it is noteworthy that coronary inflammation was most pronounced in CAD patients with a CAC score of 0, while CAC score did not demonstrate an association with inflammation.
Jing et al. (Tue,) conducted a cross-sectional in Coronary artery disease (n=346). Computed tomography assessment of PCAT attenuation and CAC vs. Non-CAD patients and varying CAC scores was evaluated on PCAT attenuation values across different CAC scores and CAD status (p=0.000). Coronary inflammation was significantly higher in CAD patients compared to non-CAD patients (-87.54 vs. -93.45 HU, P=0.000), but did not correlate with coronary artery calcium score severity.