Accelerated ungated, free-breathing spiral-in/out bSSFP sequences yielded clinically diagnostic images with a global quality score of 3.9 compared to 4.4 for standard breath-hold cine, while maintaining good agreement in left ventricular ejection fraction.
Does accelerated ungated, free-breathing dynamic cardiac MRI using spiral-based bSSFP sequences provide comparable image quality and LVEF measurements to standard ECG-gated breath-hold Cartesian cine in healthy volunteers?
Accelerated spiral-based bSSFP sequences with L+S reconstruction enable ungated, free-breathing dynamic cardiac MRI in 45 seconds with diagnostic image quality and accurate LVEF quantification, offering a faster alternative to standard breath-hold cine.
Absolute Event Rate: 3.9% vs 4.4%
p-value: p=<0.05
OBJECTIVE: To develop two spiral-based bSSFP pulse sequences combined with L + S reconstruction for accelerated ungated, free-breathing dynamic cardiac imaging at 1.5 T. MATERIALS AND METHODS: Tiny golden angle rotated spiral-out and spiral-in/out bSSFP sequences combined with view-sharing (VS), compressed sensing (CS), and low-rank plus sparse (L + S) reconstruction were evaluated and compared via simulation and in vivo dynamic cardiac imaging studies. The proposed methods were then validated against the standard cine, in terms of quantitative image assessment and qualitative quality rating. RESULTS: The L + S method yielded the least residual artifacts and the best image sharpness among the three methods. Both spiral cine techniques showed clinically diagnostic images (score > 3). Compared to standard cine, there were significant differences in global image quality and edge sharpness for spiral cine techniques, while there was significant difference in image contrast for the spiral-out cine but no significant difference for the spiral-in/out cine. There was good agreement in left ventricular ejection fraction for both the spiral-out cine (- 1.6 Formula: see text 3.1%) and spiral-in/out cine (- 1.5 Formula: see text 2.8%) against standard cine. DISCUSSION: ) and temporal resolution (36 ms) per slice for whole heart coverage (10-15 slices) within 45 s, suggesting the clinical potential for improved patient comfort or for imaging patients with arrhythmias or who cannot hold their breath.
Wang et al. (Mon,) conducted a other in Healthy volunteers (cardiac imaging) (n=7). Spiral-in/out bSSFP sequence with L+S reconstruction vs. Standard ECG-gated breath-hold Cartesian bSSFP cine sequence was evaluated on Global image quality score (1-5 scale) (p=<0.05). Accelerated ungated, free-breathing spiral-in/out bSSFP sequences yielded clinically diagnostic images with a global quality score of 3.9 compared to 4.4 for standard breath-hold cine, while maintaining good agreement in left ventricular ejection fraction.