Proteome analysis of post-mortem biological samples is a promising tool for diagnosing the etiology of sudden cardiac death in forensic settings.
Does proteome analysis improve the diagnosis of sudden cardiac death in forensic settings?
Proteome analysis of post-mortem samples represents a promising tool to improve the diagnosis and understanding of sudden cardiac death in forensic settings.
Sudden cardiac death (SCD) represents a global emergency, with a high number of cases affecting all age groups every year. The prevention of these fatal events requires an accurate knowledge of etiology and pathogenesis, which can vary. Autopsy is an indispensable tool in cases of SCD for diagnostic purposes, as well as for judicial and preventive purposes for family members. Despite the completion of all routine post-mortem investigations, it is often complicated for the forensic pathologist to define the triggering cause of these events. The study of the proteome is proving to be extremely promising in the field of human cardiovascular disease. This paper aims to offer a literature review on the study of the proteome in post-mortem cadaveric biological samples obtained from SCD cases. The aim of this work is to outline the state of the art of the scientific advances that protein analysis can offer in the diagnosis of SCD and the limits that various studies have traced up to now. In conclusion, the work defines the future perspectives of this field in SCD, suggesting strategies to overcome the reported limits and improve the diagnostics of these events.
Sacco et al. (Wed,) conducted a review in Sudden cardiac death (SCD). Proteome analysis was evaluated. Proteome analysis of post-mortem biological samples is a promising tool for diagnosing the etiology of sudden cardiac death in forensic settings.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: