Providing additional metabolic substrates improved contractility in failing human cardiomyocytes compared to using carbohydrates alone.
Do different fuel substrates improve contractility in failing human cardiomyocytes compared to carbohydrates alone?
Alternative metabolic substrates improve contractility in failing human cardiomyocytes, demonstrating the functional significance of fuel utilization shifts in heart failure.
Recent studies suggest that metabolic dysregulation in patients with heart failure might contribute to myocardial contractile dysfunction. To understand the correlation between function and energy metabolism, we studied the impact of different fuel substrates on human nonfailing or failing cardiomyocytes. Consistent with the concept of metabolic flexibility, nonfailing myocytes exhibited excellent contractility in all fuels provided. However, impaired contractility was observed in failing myocytes when carbohydrates alone were used but was improved when additional substrates were added. This study demonstrates the functional significance of fuel utilization shifts in failing human cardiomyocytes.
Vite et al. (Wed,) conducted a other in Heart failure. Alternative metabolic substrates vs. Carbohydrates alone was evaluated on Contractility. Providing additional metabolic substrates improved contractility in failing human cardiomyocytes compared to using carbohydrates alone.