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Progress in treatment for glioblastoma is hindered by the blood-brain barrier (BBB). In genetic mouse models recapitulating brain invasion and abnormal angiogenesis of human glioblastoma, Cai and colleagues demonstrate that optical modulation of the BBB with nanoparticles boosts intratumoural chemotherapy concentration, prolonging survival. We discuss prospects for clinical translation of exemplary innovative techniques.
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Imran Noorani
Jorge de la Rosa
Nature Communications
University of Cambridge
University College London
National Hospital for Neurology and Neurosurgery
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Noorani et al. (Fri,) studied this question.
www.synapsesocial.com/papers/6a0010b04716aad0cc859277 — DOI: https://doi.org/10.1038/s41467-023-41694-9
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