Cardiomyocyte size and desmin expression significantly increased during early remodeling in Stage A of ischemic heart failure compared to controls (p < 0.001), progressing through Stages B and C/D.
Observational (n=84)
Significant morphological changes and cytoskeletal reorganization in cardiomyocytes occur during the earliest stages of remodeling prior to symptomatic ischemic heart failure.
p-value: p=<0.001
Although major pathogenesis mechanisms of heart failure (HF) are well established, the significance of early (mal)adaptive structural changes of cardiomyocytes preceding symptomatic ischemic HF remains ambiguous. The aim of this study is to present the morphological characterization of changes in cardiomyocytes and their reorganization of intermediate filaments during remodeling preceding symptomatic ischemic HF in an adult human heart. A total of 84 myocardial tissue samples from middle-left heart ventricular segments were analyzed histomorphometrically and immunohistochemically, observing the cardiomyocyte’s size, shape, and desmin expression changes in the remodeling process: Stage A of HF, Stage B of HF, and Stages C/D of HF groups (ACC/AHA classification). Values p 0.05), and most intense in Stages C/D of HF (p < 0.001). Significant morphological changes of cardiomyocytes and their cytoskeletal reorganization were observed during the earliest remodeling events preceding symptomatic ischemic HF.
Kuprytė et al. (Tue,) conducted a observational in Ischemic heart failure (n=84). Ischemic heart failure stages (A, B, C/D) vs. Control group was evaluated on Cardiomyocyte cellular length, diameter, volume, and desmin expression (p=<0.001). Cardiomyocyte size and desmin expression significantly increased during early remodeling in Stage A of ischemic heart failure compared to controls (p < 0.001), progressing through Stages B and C/D.
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