Administration of 3-IAId significantly mitigated aortic dissection and rupture rates (45% vs. 90%) and reduced mortality rates (20% vs. 55%) in a BAPN-induced murine model.
Does Indole-3-aldehyde (3-IAId) reduce aortic dissection and mortality in a BAPN-induced murine model?
3-IAId administration significantly reduces aortic dissection, rupture, and mortality in a murine model by inhibiting VSMC phenotype transition and inflammation.
Absolute Event Rate: 45% vs 90%
Tryptophan, an essential dietary amino acid, is metabolized into various metabolites within both gut microbiota and tissue cells. These metabolites have demonstrated potential associations with panvascular diseases. However, the specific relationship between tryptophan metabolism, particularly Indole-3-aldehyde (3-IAId), and the occurrence of aortic dissection (AD) remains unclear. 3-IAId showed an inverse association with advanced atherosclerosis, a risk factor for AD. In this study, we employed a well-established β-aminopropionitrile monofumarate (BAPN)-induced AD murine model to investigate the impact of 3-IAId treatment on the progression of AD. Our results reveal compelling evidence that the administration of 3-IAId significantly mitigated aortic dissection and rupture rates (BAPN + 3-IAId vs. BAPN, 45% vs. 90%) and led to a notable reduction in mortality rates (BAPN + 3-IAId vs. BAPN, 20% vs. 55%). Furthermore, our study elucidates that 3-IAId exerts its beneficial effects by inhibiting the phenotype transition of vascular smooth muscle cells (VSMCs) from a contractile to a synthetic state. It also mitigates extracellular matrix degradation, attenuates macrophage infiltration, and suppresses the expression of inflammatory cytokines, collectively contributing to the attenuation of AD development. Our findings underscore the potential of 3-IAId as a promising intervention strategy for the prevention of thoracic aortic dissection, thus providing valuable insights into the realm of vascular disease management.
Huang et al. (Tue,) conducted a other in Aortic dissection. Indole-3-aldehyde (3-IAId) vs. BAPN alone was evaluated on Aortic dissection and rupture rates. Administration of 3-IAId significantly mitigated aortic dissection and rupture rates (45% vs. 90%) and reduced mortality rates (20% vs. 55%) in a BAPN-induced murine model.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: