Serum β2-microglobulin ≥25 µg/L was associated with a significantly higher risk of cardiac valve calcification in maintenance hemodialysis patients (OR 3.39; 95% CI 1.63-7.06; P=0.001).
Observational
No
Does elevated serum β2-microglobulin predict the occurrence of cardiac valve calcification in maintenance hemodialysis patients?
Elevated serum β2-microglobulin (≥25 µg/L) is an independent predictor of cardiac valve calcification in maintenance hemodialysis patients.
Effect estimate: OR 3.39 (95% CI 1.63-7.06)
p-value: p=0.001
Background: Cardiac valve calcification (CVC) is associated with adverse cardiovascular events. We studied the risk factors of CVC in maintenance hemodialysis (MHD) patients and the value of serum β2-microglobulin (β2-MG) levels in predicting the incidence of CVC. β2-MG is a middle molecular weight toxin. In recent years, researchers found that elevated blood β2-MG was associated with coronary, thoracic, and abdominal aortic calcifications with significant correlations. β2-MG has been emerging as a strong biomarker for cardiovascular mortality in uremic patients but its role in CVC is not well studied. This study looked specifically at CVC occurrence in relation to β2-MG for MHD patients. Methods: Patients who underwent MHD for more than 3 months in the First People's Hospital of Nantong City from November 2012 to November 2019 with complete available data were included in the study. The patients were divided into the CVC group and the non-CVC group. The general information and clinical laboratory indicators of the patients were collected in a retrospective manner. We analyzed the risk factors for developing CVC in MHD patients using binary logistic regression method. Receiver operating characteristic (ROC) curves were used to calculate the cut-off value of β2-MG for predicting CVC. The decision tree (DT) method was used to classify and explore the probability of CVC in patients with MHD. Results: =6.750, P69 years were important determinants for predicting CVC in MHD patients. Conclusions: Serum β2-MG in MHD patients has a positive correlation with the severity and occurrence of CVC.
Shen et al. (Fri,) conducted a observational in Maintenance hemodialysis (MHD). Serum β2-microglobulin (β2-MG) ≥25 µg/L vs. Serum β2-microglobulin <25 µg/L was evaluated on Cardiac valve calcification (CVC) (OR 3.39, 95% CI 1.63-7.06, p=0.001). Serum β2-microglobulin ≥25 µg/L was associated with a significantly higher risk of cardiac valve calcification in maintenance hemodialysis patients (OR 3.39; 95% CI 1.63-7.06; P=0.001).