High-sensitivity C-reactive protein concentrations >3 mg/L are associated with an increased risk of developing chronic heart failure, with levels directly correlating with disease severity and mortality.
Does high-sensitivity C-reactive protein predict the development, severity, and prognosis of chronic heart failure?
High-sensitivity C-reactive protein levels above 3 mg/l serve as a useful biomarker for predicting the risk, severity, and prognosis of chronic heart failure.
Cardio vascular diseases (CVD) are one of the most serious problems of modern medicine both throughout the world and in the Russian Federation, due to their high prevalence and high risk of death. A signif-icant contribution to the rates of hospitalization and mortality from cardiovascular diseases is made by chronic heart failure (CHF), which is a severe pathology. The key strategic direction to reduce mortality from CHF and increase life expectancy of the population is the search for methods aimed at prevention and early detection of heart failure. This literature review summarizes research data on the relationship between high-sensitivity C-reactive protein (hs-CRP) and various aspects of cardiovascular events (CVS) (risk of development, severity of the condition, disease prognosis), in particular chronic heart failure. The authors of the article carried out a de-scriptive synthesis of the literature to present the main characteristics of the studied biomarker, including the purpose of the measurement, the relationship with other risk factors (RF), laboratory and instrumental indicators; categories of patients for whom it is the most informative. The study was able to analyze 25 literature sources for the availability of information showing the effect of hs-CRP values in the blood of patients on the course of CVD. A threshold concentration of this biomarker (3 mg/l) was established, which is associated with an increased risk of developing CHF, while the severity of its course directly correlated with the degree of CRP increase, as well as the risk of its progression and death from this disease (complications).
Tokmachev et al. (Mon,) conducted a review in Chronic heart failure. High-sensitivity C-reactive protein (hs-CRP) vs. Lower hs-CRP levels was evaluated. High-sensitivity C-reactive protein concentrations >3 mg/L are associated with an increased risk of developing chronic heart failure, with levels directly correlating with disease severity and mortality.