Culturing cardiac fibroblasts on hydrogels of varying stiffness modulates their activation, senescence, and secretory phenotype, highlighting stiffness-dependent signaling networks.
Our findings highlight the advantages and pitfalls associated with culturing cardiac fibroblasts on hydrogels of varying stiffness. The findings also define stiffness-dependent signaling and transcriptional networks in cardiac fibroblasts.
Felisbino et al. (Fri,) studied this question.