What is the clinical evidence from this study?

Study design: Cohort. Population: Geriatric hip fractures (n=1465). Intervention: Admission pH 7.39. Primary outcome: Preoperative deep vein thrombosis (DVT) (OR 19.47, 95% CI 1.45-260.91, p=0.0249).

October 26, 2023Open Access

The admission pH is a risk factor of preoperative deep vein thrombosis in geriatric hip fracture: a retrospective cohort study

BWBaohui WangChongqing University of Science and Technology YSYin-Di SunXi'an Honghui Hospital XFXiaochen FanCardiovascular Institute of the South

Key Result

In geriatric patients with hip fractures, an admission pH below 7.39 was significantly associated with an increased risk of preoperative deep vein thrombosis (OR 19.47).

Study Design

Type

Cohort (n=1,465)

Multicenter

Structured PICO

Does admission pH value predict preoperative DVT in geriatric patients with hip fractures?

Population

1,465 older adults (aged ≥65 years) with hip fractures admitted to a trauma center in China, evaluated for the association between admission pH and preoperative deep vein thrombosis.

Exposure

Admission blood pH value

Outcome

Preoperative deep vein thrombosis (DVT) diagnosed by Doppler ultrasonographyhard clinical

Admission pH is nonlinearly associated with preoperative DVT in geriatric hip fracture patients, with pH < 7.39 significantly increasing the risk of DVT.

Main Result

Odds Ratio: 19.47 (95% CI 1.45–260.91)

p-value: p=0.0249

Limitations

Retrospective study design cannot determine a causal relationship
Study population from a single center in Northwest China may introduce selection bias
Findings may not be generalizable to the entire population

Abstract

This study evaluated the association between body pH value and preoperative deep vein thrombosis (DVT) in geriatric hip fractures. Older adult patients with hip fractures were screened between January 2015 and September 2019. The demographic and clinical characteristics of the patients were collected. Multivariate binary logistic regression and generalized additive models were used to identify the linear and nonlinear associations between pH value and preoperative DVT. Analyses were performed using EmpowerStats and R software. A total of 1465 patients were included in the study. DVT occurred in 476 (32.6%) of these admitted older adults. We observed a nonlinear association between the serum pH value and preoperative DVT in geriatric patients with hip fractures. A pH value of 7.39 was the inflection point in the curve, with pH highly correlated with DVT at pH 7.39, pH was not correlated with DVT (OR 1.26; 95% CI 0.85-1.86; P = 0.2561), the odds of DVT did not vary with pH, and the highest risk of thrombosis was reached. The body pH value is nonlinearly associated with preoperative DVT in geriatric patients with hip fractures, and it could be considered a predictor of the risk of DVT.Registered information This study is registered in the website of Chinese Clinical Trial Registry (ChiCTR: ChiCTR2200057323).

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