Nonvalvular atrial fibrillation was associated with significantly higher levels of inflammatory and coagulation markers compared to controls, which correlated with structural atrial remodeling.
Case-Control (n=283)
Are inflammation and coagulation markers elevated in patients with nonvalvular AF compared to controls, and do they correlate with structural atrial remodeling?
Elevated inflammatory and coagulation markers in nonvalvular AF correlate with structural atrial remodeling, highlighting interconnected pathophysiological pathways in AF pathogenesis.
Introduction: Atrial fibrillation (AF) is associated with elevated levels of clotting factors such as tissue factor (TF) and factor XII (FXII). Various inflammation markers, such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF- α), and high-sensitive C-reactive protein (hs-CRP), have also been associated with AF. This study explores the relationship between inflammation markers and coagulation activity, including their impact on heart structural changes in these patients. Methods: We observed 283 patients with nonvalvular AF who underwent a complete examination at admission, but only 183 patients have successful cardioversion. As a control group, similar patients without AF were examined. The markers of the coagulation and inflammation were studied by ELISA on the analyzer "Stat Fax 303 Plus". Studies were conducted using l statistical package SPSS 13.0. Results: It was revealed that patients with AF had significantly higher levels of hs-CRP, IL-6, and TNF-α and had elevated levels of TF and FXII compared with control group. The moderate correlations were observed between IL-6 and left atrial diameter (LAD), IL-6 and LA stiffness, hs-CRP and left atrial volume (LAV), TF and LAV. Conclusion: We have demonstrated that patients with AF have the relationship between elevated levels of inflammatory markers and coagulation activity, which contributes to structural atrial remodeling.
Hazarapetyan et al. (Sun,) conducted a case-control in Nonvalvular atrial fibrillation (n=283). Nonvalvular atrial fibrillation (exposure) vs. Patients without atrial fibrillation was evaluated on Levels of inflammatory markers (hs-CRP, IL-6, TNF-α) and coagulation factors (TF, FXII). Nonvalvular atrial fibrillation was associated with significantly higher levels of inflammatory and coagulation markers compared to controls, which correlated with structural atrial remodeling.