Regions with Altered Degree Centrality and Their Functional Connectivity in First-Episode Drug-Naïve Major Depressive Disorder: A Resting-State Functional Magnetic Resonance Imaging Study

Objective: The aim of this study was to identify regions with altered degrees of centrality (DC) and changes in their functional connectivity (FC) in first-episode drug-naïve major depressive disorder (FEDN-MDD) patients using resting-state functional magnetic resonance imaging (fMRI). Methods: The study included 74 FEDN-MDD patients who met the study criteria and 41 healthy controls (HCs). All had undergone fMRI scanning in the resting condition. To evaluate differences between FEDN-MDD patients and HCs, we first compared the DC between the 2 groups. The DC regions with the most significant differences were then taken as seeds, and their FC was calculated. Results: -values for cluster testing were .050, while for voxel testing they were .001. Conclusion: These findings imply that PUT.R, PCUN.R, and PCC.R serve as the core brain net hub in FEDN-MDD patients, and their FC displays aberrant function. This may involve a specific psychiatric neuropathology associated with FEDN-MDD.