Women surviving aortic valve intervention had a higher rate of heart failure readmissions at 5 years compared to men (23% vs 9%; p=0.046), but no difference in overall mortality.
Observational (n=451)
Yes
Do clinical outcomes and mortality differ by sex in patients with symptomatic severe aortic stenosis after aortic valve intervention?
Women with severe aortic stenosis undergo valve intervention at a more advanced disease stage than men, leading to higher long-term heart failure readmissions but similar overall mortality.
Absolute Event Rate: 23% vs 9%
p-value: p=0.016
There are known pathophysiologic and clinical differences according to sex in patients with aortic stenosis (AS). To evaluate if these differences persist after valve replacement, we conducted an observational study including 451 patients with symptomatic AS who survived aortic valve intervention (AVI) in two centers. Clinical data and mortality were evaluated at a mean follow-up of 5 years. 56% of patients were women. At baseline, women were older (80.6 vs. 78 years, p = 0.013), presented higher mean gradient (48 vs. 45 mmHg, p = 0.023), lower aortic valve area (0.70 vs. 0.74 cm2, p = 0.002) and higher systolic pulmonary artery pressure (36 vs. 33 mmHg, p = 0.016). They underwent percutaneous aortic valve replacement more frequently than men (47 vs. 35.9%, p = 0.017). At 5 years follow-up, women required more admissions due to heart failure (23 vs. 9%, p = 0.046) but they did not present higher cardiovascular nor overall mortality (27.7% vs. 29.8%, p = 0.741; 11.1 vs. 10.1%, p = 0.619, respectively). Female sex was an independent predictor of heart failure hospitalization at follow-up (HR 95% 1.16–4.22, p = 0.016). Women undergo AVI at a more advanced stage than men, resulting in a higher frequency of readmissions due to heart failure during the follow-up period, but not in higher mortality.
Sevilla et al. (Fri,) conducted a observational in Symptomatic aortic stenosis (n=451). Female sex vs. Male sex was evaluated on Heart failure hospitalization (95% CI 1.16-4.22, p=0.016). Women surviving aortic valve intervention had a higher rate of heart failure readmissions at 5 years compared to men (23% vs 9%; p=0.046), but no difference in overall mortality.