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The economic and practical strategies of direct nucleophilic attack/addition cyclization and C-H bond activation reactions to synthesize 3-benzyl-/3-benzyl-2-phenyl-benzo4,5imidazo2,1-bthiazoles via (Z)-(2,3-dibromoprop-1-en-1-yl)benzene/(3-bromoprop-1-yn-1-yl)benzene, 1H-benzodimidazole-2-thiols and halobenzenes have been developed. With the optimized reaction conditions, the nucleophilic attack/addition cyclization reaction (Cs2CO3, MeCN, 90 °C, 24 h) and C-H bond activation reaction Pd(OAc)2/PPh3, p-xylene, 135 °C, 24 h could tolerate various electron-donating and electron-withdrawing groups and afford new benzo4,5imidazo2,1-bthiazoles in good to excellent yields (up to 93% yield).
Wang et al. (Sun,) studied this question.
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