Does point-by-point pulsed field ablation produce durable lesions compared to radiofrequency ablation in a chronic swine heart model?
Point-by-point pulsed field ablation guided by contact force creates durable lesions and mature scars without collateral injury in a swine model, supporting its potential for atrial fibrillation treatment.
In a randomized preclinical study, focally delivered unipolar/biphasic PFA guided by contact force values was associated with durable lesions on chronic remapping and with mature scar formation on histology without signs of collateral injury on necroscopy. Further studies are needed to investigate the long-term feasibility of this new approach to atrial fibrillation treatment.
Biase et al. (Thu,) studied this question.