Human induced pluripotent stem cell (iPSC) platforms combined with genomic tools are advancing precision cardiovascular medicine through genetic prediction, disease modeling, and drug screening.
Human induced pluripotent stem cell (iPSC) platforms are valuable for biomedical and pharmaceutical research by providing tissue-specific human cells that retain patients' genetic integrity and display disease phenotypes in a dish. Looking forward, combining iPSC phenotyping platforms with genomic and screening technologies will continue to pave new directions for precision medicine, including genetic prediction, visualization, and treatment of heart disease. This review summarizes the recent use of iPSC technology to unpack the influence of genetic variants in cardiovascular pathology. We focus on various state-of-the-art genomic tools for cardiovascular therapies-including the expansion of genetic toolkits for molecular interrogation, in vitro population studies, and function-based drug screening-and their current applications in patient- and genome-edited iPSC platforms that are heralding new avenues for cardiovascular research.
Caudal et al. (Mon,) conducted a review in Cardiovascular disease. Human induced pluripotent stem cell (iPSC) platforms and genomic tools was evaluated. Human induced pluripotent stem cell (iPSC) platforms combined with genomic tools are advancing precision cardiovascular medicine through genetic prediction, disease modeling, and drug screening.