Elevated cardiac troponin I was independently associated with an increased risk of unfavorable short-term outcomes (OR 8.25) and lower 90-day survival in patients with acute ischemic stroke.
Cohort (n=100)
No
Does elevated baseline cardiac troponin I predict unfavorable functional outcomes and mortality in patients with acute ischemic stroke?
Elevated baseline cardiac troponin I is a strong, independent predictor of 90-day mortality and unfavorable functional outcomes in patients with acute ischemic stroke.
Odds Ratio: 8.25 (95% CI 2.65–25.75)
p-value: p=<0.001
OBJECTIVE: To assess if elevated cardiac troponin I (cTnI) serves as a sign of unfavorable functional outcomes in ischemic stroke. METHODS: In this single-center prospective cohort study, 100 consecutive patients admitted with acute ischemic stroke (normal troponin I group n = 52, raised troponin I group n = 48) were included. Hospital mortality was documented in both groups; the remaining patients were followed up to 90 days. Then two groups were compared in terms of unfavorable short-term outcomes (Modified Rankin Scale > 3) and mortality. Multivariate logistic regression was conducted to determine the predictive value of elevated cTnI. The Kaplan-Meier curve was drawn and compared to determine the difference in survival between the two groups. To find out the most probable cut-off level for an unfavorable outcome, a receiver operating characteristic (ROC) analysis was conducted. RESULT: A higher frequency of coronary artery disease (p=0. 030), higher National Institutes of Health Stroke Scale (NIHSS) (p=0. 008) score, and lower Glasgow Coma Scale (GCS) (p=0. 002) was observed in raised troponin I group. Even after the exclusion of confounding elevated troponin I was found to be an independent predictor of unfavorable outcomes (adjusted odds ratio, OR 8. 25 95% confidence interval, CI: 2. 65-25. 75; p<0. 001). The patients with raised troponin I had a significantly lower rate of survival after 90 days (p=0. 022). The elevated troponin I was observed to have a significantly high accuracy (p<0. 001; area under curve, AUC: 0. 768 moderate accuracy, 95% CI: 0. 676 to 0. 861) in predicting unfavorable outcomes. CONCLUSION: Elevated cTnI is independently associated with unfavorable short-term outcomes. It is also associated with a lower rate of survival.
Esteak et al. (Tue,) conducted a cohort in Acute ischemic stroke (n=100). Elevated cardiac troponin I vs. Normal troponin I was evaluated on Unfavorable short-term outcome (Modified Rankin Scale > 3) (OR 8.25, 95% CI 2.65-25.75, p=<0.001). Elevated cardiac troponin I was independently associated with an increased risk of unfavorable short-term outcomes (OR 8.25) and lower 90-day survival in patients with acute ischemic stroke.