From 1990 to 2019, the global age-standardized incidence and death rates of chronic kidney disease due to hypertension increased by 17.89% and 13.29%, reaching 19.45 and 5.88 per 100,000 population, respectively.
Observational
The global burden of hypertension-related CKD has significantly increased from 1990 to 2019, with the highest incidence in high-SDI regions and highest mortality in low-SDI regions, highlighting the need for targeted prevention and healthcare strategies.
Effect estimate: 17.89% increase (95% CI 17.85-21.09)
Absolute Event Rate: 19.45% vs 15.97%
BACKGROUND: The intricate relationship between hypertension and chronic kidney disease (CKD) presents a global challenge for prevention of hypertension-related CKD. This study's objective is to analyze age, gender, regional disparities, and evolving trends in the disease burden of hypertension-related CKD. We aim to estimate changing spatial and temporal trends in incidence and mortality rates, considering the socio-demographic index (SDI), to inform health strategies effectively. METHOD: Age-standardized incidence rates (ASIR) and death rates (ASDR) were collected from the GBD 2019. Trend analysis was conducted by Joinpoint regression of ASRs from 1990 to 2019. Spatial autocorrelation analysis was performed to obtain spatial patterns. The association between SDI and burden of CKD due to hypertension was estimated using a Pearson correlation analysis. RESULTS: The global ASIR and ASDR due to hypertension-related CKD were 19.45 (95% CI, 17.85 to 21.09) and 5.88 (95% CI, 4.95 to 6.82) per 100 K population in 2019, representing increases of 17.89% and 13.29% compared to 1990, respectively. The elderly population and males were found the highest ASIR and ASDR. The high SDI region had the highest ASIRs, while low SDI regions experienced the highest ASDRs. Joinpoint regression found both global ASIR and ASDR showed increasing trends, with the highest increases observed in middle- and high-SDI regions, respectively. The SDI exhibited a positive association with ASIRs but displayed an inverse V-shaped correlation with the average annual percentage change (AAPC) of ASIRs. Spatial autocorrelation analysis revel significant positive spatial autocorrelation for the AAPC of ASDRs and ASIRs, from 1990 to 2019. CONCLUSIONS: Results met the objectives, and demonstrated a rising global burden of hypertension-related CKD. Factors such as aging, gender, and regional variations should be considered when designing control measures and developing healthcare systems to effectively address the burden of this complex condition.
Liu et al. (Wed,) conducted a observational in Chronic kidney disease due to hypertension. Time (1990 to 2019) vs. 1990 was evaluated on Age-standardized incidence rate (ASIR) of CKD due to hypertension per 100,000 population (17.89% increase, 95% CI 17.85-21.09). From 1990 to 2019, the global age-standardized incidence and death rates of chronic kidney disease due to hypertension increased by 17.89% and 13.29%, reaching 19.45 and 5.88 per 100,000 population, respectively.