Arterial stiffness partially mediates the association between age and processing speed in the presence of low microvascular function.
Observational
Does arterial stiffness mediate the association between age and processing speed in cognitively healthy adults?
Arterial stiffness and pulse pressure are associated with processing speed in cognitively healthy adults, suggesting vascular factors could be targets for preventing cognitive decline.
Arterial stiffness partially mediates the association between age and processing speed in the presence of low microvascular function, as demarcated by maximum tissue oxygenation following ischemia. Central and peripheral pulse pressure remained associated with processing speed even after controlling for age. Our findings were derived from a sample that was determined to be cognitively healthy, which highlights the potential for these outcomes to be considered during trials aimed at the prevention of cognitive decline.
Ransom et al. (Fri,) conducted a observational in Cognitively healthy. Arterial stiffness and low microvascular function was evaluated on Processing speed. Arterial stiffness partially mediates the association between age and processing speed in the presence of low microvascular function.