In patients with severe acute heart failure, total and most individual serum free fatty acids were significantly positively correlated with serum albumin, with few other clinical associations.
Observational (n=304)
Are baseline serum free fatty acids associated with clinical and laboratory indicators of heart failure severity in patients with acute heart failure?
In patients with severe acute heart failure, individual and total serum free fatty acids show only slight associations with established laboratory and clinical parameters of heart failure severity.
Very little is known about the association between individual serum free fatty acids (FFAs) and clinical and laboratory parameters (indicators of heart failure severity) in acute heart failure (AHF) patients. Here, the baseline serum levels of FFAs, 16:0 (palmitic acid), 16:1 (palmitoleic acid), 18:0 (stearic acid), 18:1 (oleic acid), 18:2 (linoleic acid), 18:3 (alpha-linolenic acid or gamma-linolenic acid), 20:4 (arachidonic acid), 20:5 (eicosapentaenoic acid), and 22:6 (docosahexaenoic acid), were determined in 304 AHF patients (94.7% belonged to New York Heart Association functional class IV) using gas chromatography. Spearman correlation coefficients were used to examine the associations between the individual and total (the sum of all FFAs) FFAs and clinical and laboratory parameters. After applying a Bonferroni correction to correct for multiple testing, the total FFAs, as well as the individual FFAs (except FFAs 18:0, 20:5, and 22:6), were found to be significantly positively correlated with serum albumin. Only a few additional associations were found: FFA 16:0 was significantly negatively correlated with systolic pulmonary artery pressure, FFA 18:3 was significantly negatively correlated with C-reactive protein and body mass index, and FFA 20:4 was significantly negatively correlated with blood urea nitrogen. Based on our results, we conclude that in patients with severe AHF, individual and total serum FFAs are slightly associated with established laboratory and clinical parameters, which are indicators of heart failure severity.
Klobučar et al. (Fri,) conducted a observational in Acute heart failure (n=304). Serum free fatty acids (FFAs) was evaluated on Associations between individual and total FFAs and clinical and laboratory parameters. In patients with severe acute heart failure, total and most individual serum free fatty acids were significantly positively correlated with serum albumin, with few other clinical associations.