Vascular calcification accelerates cardiac dysfunction, partially by inducing cardiomyocyte apoptosis, as demonstrated by increased pulse propagation velocity and altered gene expression in murine models.
Does aortic calcification induce cardiac dysfunction and cardiomyocyte apoptosis in mice and cell models?
Vascular calcification accelerates cardiac dysfunction partially by inducing cardiomyocyte apoptosis.
-treated mice displayed a significant aortic calcification, increased pulse propagation velocity of aortae, and reduced cardiac function. Aortae showed increased calcification and elastolysis, with increased heart apoptosis. Hearts demonstrated higher levels of ANP, BNP, MMP2, and lower levels of bcl2/bax. Moreover, calcified rat VSMC media induced H9C2 apoptosis and upregulated genes expression linked to cardiac dysfunction. Our data provide evidence that VC accelerates cardiac dysfunction, partially by inducing cardiomyocytes apoptosis.
Hao et al. (Tue,) conducted a other in Aortic calcification and cardiac dysfunction. Aortic calcification was evaluated on Cardiac dysfunction and cardiomyocyte apoptosis. Vascular calcification accelerates cardiac dysfunction, partially by inducing cardiomyocyte apoptosis, as demonstrated by increased pulse propagation velocity and altered gene expression in murine models.