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The example of iron-catalyzed reductive fluoroalkylalkenylation of unactivated alkenes has been disclosed, affording the stereodefined homoallylic fluoroalkanes with high efficiency and regioselectivity. This three-component cross-electrophile coupling features directing groups free, good functional group tolerance, broad substrate scope, and late-stage difunctionalization of biorelevant molecules. Moreover, this protocol sheds light on the distinct reactivity disparities between fluoroalkyl and nonfluoroalkyl radicals in three-component reductive cross-coupling reactions, highlighting the unique nature of iron/B2pin2 systems.
Wang et al. (Tue,) studied this question.